Toxicology and Poisoning Management

The primary aim of this course will be to discuss principles of drug-induced organ injuries and their relationship to parameters in clinical toxicology, toxicity testing methods and poisoning management strategies. The didactic portion will involve discussion on mechanisms of drug or chemical-induced organ toxicity, various molecular mechanisms of cell injury and cell death, diverse cytotoxic mechanisms and drug/chemical poisoning and their management with antidotes. Special emphasis will be placed upon mechanistic approaches to understand toxin/antidote action mechanisms. The laboratory portion will cover relevant serum chemistry analysis, histopathology and some biochemical assays. Knowledge gained in this course will significantly enhance understandings of toxic effects of a variety of drugs, management of overdose situations and strategies to assess toxicities in pharmacy practice.